Dozens of firefighters were called to a blaze near the London Stadium, the home of West Ham United.
Thick black smoked billowed from the derelict building in east London on Sunday evening.
London Fire Brigade said 58 firefighters and eight fire engines were called to the fire on Wick Lane, which is close to the Queen Elizabeth Olympic Park.
Pictures and videos on Twitter showed flames and a plume of thick black smoke.
No one is believed to have been injured.
Comments: Our rules
We want our comments to be a lively and valuable part of our community - a place where readers can debate and engage with the most important local issues. The ability to comment on our stories is a privilege, not a right, however, and that privilege may be withdrawn if it is abused or misused.
Please report any comments that break our rules.
Read the rules here